{"product_id":"tribio-sbi-553-arrestin-biased-ntsr1-modulator","title":"SBI-553, ß-Arrestin-biased NTSR1 modulator","description":"\u003cp\u003eSBI-553 is a potent, brain penetrant, and orally bioavailable allosteric modulator of neurotensin receptor 1 (NTSR1; EC 50 = 340 nM)). It acts as a ß-Arrestin-biased agonist and selectively antagonizes G protein signaling conferring profound ß-Arrestin bias towards the endogenous ligand. SBI-553 displayed efficacy in mouse models of psychostimulant abuse without the characteristic undesirable side effects of unbiased NTSR1 agonism. This functionally selective modulation of NTSR1 may be a new therapeutic approach to treating psychostimulant abuse and other chemical and behavioral addictions\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411058860372,"sku":"ABM148714-1","price":581.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411058893140,"sku":"ABM148714-2","price":163.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4449.png?v=1791104976","url":"https:\/\/www.abmium.com\/de\/products\/tribio-sbi-553-arrestin-biased-ntsr1-modulator","provider":"ABMIUM","version":"1.0","type":"link"}