{"product_id":"tribio-sb-525334-alk5","title":"SB-525334, ALK5 (TGF bR1) inhibitor","description":"\u003cp\u003ePotent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model. It causes significant attenuation in Smad2\/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine. Cell permeable and active in vivo\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411057451348,"sku":"ABM148710-1","price":360.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411057484116,"sku":"ABM148710-2","price":98.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2983.png?v=1791104972","url":"https:\/\/www.abmium.com\/de\/products\/tribio-sb-525334-alk5","provider":"ABMIUM","version":"1.0","type":"link"}