{"product_id":"tribio-quinacrine-antiprotozoan-anticancer","title":"Quinacrine, Antiprotozoan; Anticancer","description":"\u003cp\u003eQuinacrine is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent. It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS. Quinacrine displayed antitumor effects an intestinal cancer mouse model and HCT116 p53-\/- xenografts via reduction in Chk1\/2 expression and cell death induction in the G2-M phase. It promotes autophagic cell death in ovarian cancer cells via downregulation of p62\/SQSTM1. Quinacrine is also an inhibitor of phospholipase A2\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"100 MG","offer_id":57411060924756,"sku":"ABM148628-1","price":82.0,"currency_code":"GBP","in_stock":true},{"title":"20 MG","offer_id":57411060957524,"sku":"ABM148628-2","price":49.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4251.png?v=1791104982","url":"https:\/\/www.abmium.com\/de\/products\/tribio-quinacrine-antiprotozoan-anticancer","provider":"ABMIUM","version":"1.0","type":"link"}