{"product_id":"tribio-ptc-209-bmi-1-inhibitor","title":"PTC-209, BMI-1 inhibitor","description":"\u003cp\u003eInhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1). It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast, head and neck, glioblastoma, prostate, colon, and rhabdomyosarcoma. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411055976788,"sku":"ABM148610-1","price":392.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411056009556,"sku":"ABM148610-2","price":106.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4022.png?v=1791104968","url":"https:\/\/www.abmium.com\/de\/products\/tribio-ptc-209-bmi-1-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}