{"product_id":"tribio-pomalidomide-cereblon-ubiquitination-inhibitor","title":"Pomalidomide, Cereblon ubiquitination inhibitor","description":"\u003cp\u003eThalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 M for CRBN-DDB1 complex. Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNFα and IL-2. Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"100 MG","offer_id":57410966815060,"sku":"ABM147576-1","price":294.0,"currency_code":"USD","in_stock":true},{"title":"20 MG","offer_id":57410966847828,"sku":"ABM147576-2","price":99.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2768.png?v=1791104196","url":"https:\/\/www.abmium.com\/de\/products\/tribio-pomalidomide-cereblon-ubiquitination-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}