{"product_id":"tribio-plx5622-csf1r-inhibitor-highly-selective","title":"PLX5622, CSF1R inhibitor (highly selective)","description":"\u003cp\u003eHighly selective (\u0026gt;20 fold over KIT and FLT3, \u0026gt;60 fold over 200 other kinases) and brain-penetrant inhibitor of colony-stimulating factor 1 receptor (CSF1R; IC50 = 16 nM). It prevented plaque formation in 5xFAD and 3xTg mouse models of Alzheimer’s disease via elimination of microglia in a CSF1R-dependent manner. PLX5622 showed efficacy in a mouse neuropathic pain model via reduction of CD86+ macrophages resulting in reduced expression of pro-inflammatory cytokines. It also was able to ameliorate peripheral neuropathy in aging mice. PLX5622 displayed neuroprotective effects during the chronic phase of a traumatic brain injury mouse model. PLX5622 has also been shown to affect myeloid and lymphoid compartments, indicating that its affects are not limited to microglia and include peripheral immune cells\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410963669332,"sku":"ABM147569-1","price":360.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410963702100,"sku":"ABM147569-2","price":114.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4726.png?v=1791104190","url":"https:\/\/www.abmium.com\/de\/products\/tribio-plx5622-csf1r-inhibitor-highly-selective","provider":"ABMIUM","version":"1.0","type":"link"}