{"product_id":"tribio-nnmt-activity-assay-kit-colorimetric-fluorometric","title":"NNMT Activity Fluorometric Assay Kit","description":"\u003cp\u003eNNMT (Nicotinamide N-Methyltransferase) is an enzyme that catalyzes the methylation of nicotinamide (NA) and other pyridines using S-adenosyl-L-methionine (SAM) as the methyl group donor to produce SAH and 1-methylnicotinamide (MNA). NNMT plays a significant role in the regulation of metabolic pathways. It is expressed at high levels in several kinds of cancers, neurodegenerative diseases, obesity, and diabetes, indicating a potential target for therapy\u003c\/p\u003e\n\u003cp\u003eTribioscience’s NNMT Activity Assay utilizes SAM and nicotinamide as the substrates to generate SAH which is hydrolyzed to form homocysteine. The free thiol group of the homocysteine can be detected with a thiol probe generating an enhanced fluorescent signal at Ex\/Em = 400\/465 nm. The assay principle is displayed in Figure 1. The kit provides the easiest and most accurate approach to measure NNMT activity in a variety of samples\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"100 tests","offer_id":57411013280084,"sku":"ABM148031-1","price":472.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBS2098-1.jpg?v=1791104617","url":"https:\/\/www.abmium.com\/de\/products\/tribio-nnmt-activity-assay-kit-colorimetric-fluorometric","provider":"ABMIUM","version":"1.0","type":"link"}