{"product_id":"tribio-nh125-eukaryotic-elongation-factor-2-eef-2-kinase-inhibitor","title":"NH125, Eukaryotic elongation factor 2 (eEF-2) kinase inhibitor","description":"\u003cp\u003eNH125 was originally discovered as an antibacterial agent active against various Gram-positive and -negative bacteria via inhibition of histidine protein kinase. It was also found to be a potent inhibitor of eukaryotic elongation factor 2 (eEF-2) kinase (IC50 = 60 nM) with efficacy against a broad spectrum of human cancer cell lines. Other studies have linked the anticancer effects of NH125 to induction of eEF2 phosphorylation. NH125 has also been shown to engage the EIF2a-ATF4-CHOP axis resulting in induction of DR5 expression. Treatment of glioma stem cells with NH125 resulted in a sustained decrease in tumor volume via activation of integrated stress response (ISR) and GADD45 pathways\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410942730580,"sku":"ABM147418-1","price":432.0,"currency_code":"USD","in_stock":true},{"title":"5 MG","offer_id":57410942763348,"sku":"ABM147418-2","price":128.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4840.png?v=1791104003","url":"https:\/\/www.abmium.com\/de\/products\/tribio-nh125-eukaryotic-elongation-factor-2-eef-2-kinase-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}