{"product_id":"tribio-nacm-opt-nedd8-ligation-inhibitor","title":"NAcM-OPT, NEDD8 ligation inhibitor","description":"\u003cp\u003eA potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro). It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M\/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex. NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410936602964,"sku":"ABM147402-1","price":245.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410936635732,"sku":"ABM147402-2","price":90.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1636.png?v=1791103989","url":"https:\/\/www.abmium.com\/de\/products\/tribio-nacm-opt-nedd8-ligation-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}