{"product_id":"tribio-ml-sa1-trpml-channel-activator","title":"ML-SA1, TRPML channel activator","description":"\u003cp\u003eTRPML 1,2 and 3 channel activator. Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM). Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57410937553236,"sku":"ABM147359-1","price":123.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57410937586004,"sku":"ABM147359-2","price":490.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1439-1.png?v=1791103991","url":"https:\/\/www.abmium.com\/de\/products\/tribio-ml-sa1-trpml-channel-activator","provider":"ABMIUM","version":"1.0","type":"link"}