{"product_id":"tribio-maraviroc-ccr5-antagonist","title":"Maraviroc, CCR5 antagonist","description":"\u003cp\u003ePotent and selective CCR5 antagonist with strong anti-HIV activity. Prevents HIV-1 gp120 binding to CCR5, preventing cell-cell fusion. Inhibited MIP-1a (IC50 = 3.3 nM), MIP-1b (IC50 = 7.2 nM), and RANTES (IC50 = 5.2 nM) binding to CCR5-expressing HEK-293 cells. Clinically useful antiretroviral drug. Many cancer cells express CCR5: Maraviroc blocks metastasis of basal breast and pancreatic cancer cells, induces cytotoxic and apoptotic effects in colorectal cancer cells, reduces metastatic tumor growth in lungs, and suppresses growth in acute ALL cells. CCR inhibition with maraviroc induces macrophage repolarization with anti-tumoral effects\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410937225556,"sku":"ABM147306-1","price":358.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410937258324,"sku":"ABM147306-2","price":96.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4260.png?v=1791103990","url":"https:\/\/www.abmium.com\/de\/products\/tribio-maraviroc-ccr5-antagonist","provider":"ABMIUM","version":"1.0","type":"link"}