{"product_id":"tribio-het0016-20-hete-biosynthesis-inhibitor","title":"HET0016, 20-HETE biosynthesis inhibitor","description":"\u003cp\u003eInhibits 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis via omega oxidation of arachidonic acid mediated by CYP4A and 4F (IC 50 =8.9 nM in human renal microsomes). It displays neuroprotective effects in a rat model of traumatic brain injury via inhibition of neuronal pyroptosis. It attenuates cerebral ischemia-reperfusion injury as well as oxidative injury and peripheral nerve damage in type-2 diabetic mice. It alleviates myocardial oxidative stress and restores endothelial function, suggesting therapeutic potential in obesity-associated vascular disease\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410919039316,"sku":"ABM147133-1","price":500.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410919072084,"sku":"ABM147133-2","price":118.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI5246.png?v=1791103637","url":"https:\/\/www.abmium.com\/de\/products\/tribio-het0016-20-hete-biosynthesis-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}