{"product_id":"tribio-gsk2656157-perk-inhibitor","title":"GSK2656157, PERK inhibitor","description":"\u003cp\u003ePotent (IC50 = 0.9 nM) and selective (over 300 kinases) inhibitor of protein kinase RNA-like endoplasmic reticulum kinase (PERK). Inhibited growth of multiple human tumor xenografts in mice. Also potently inhibits RIPK1 (IC50 = 69 nM) and TNF-mediated RIPK1 kinase-dependent cell death in MEFs. Prevented the loss of dendritic spines and rescued memory deficits after traumatic brain injury. Enhances glucose-stimulated insulin secretion in a mouse model of type 2 diabetes mellitus\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410907865428,"sku":"ABM147101-1","price":262.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410907898196,"sku":"ABM147101-2","price":65.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4855.png?v=1791103612","url":"https:\/\/www.abmium.com\/de\/products\/tribio-gsk2656157-perk-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}