{"product_id":"tribio-fli-06-notch-pathway-inhibitor","title":"FLI-06, Notch pathway inhibitor","description":"\u003cp\u003eFLI-06 was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER and is thus a novel agent acting at an early stage in secretory traffic (EC50=2.3 μM). Abolishes MFAP5-dependent transcriptional programs which are upregulated in intrahepatic cholangiocarcinoma. Suppresses proliferation and induces apoptosis in esophogeal squamous cell carcinoma cells\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410916942164,"sku":"ABM147034-1","price":425.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410916974932,"sku":"ABM147034-2","price":106.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1504.png?v=1791103632","url":"https:\/\/www.abmium.com\/de\/products\/tribio-fli-06-notch-pathway-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}