{"product_id":"tribio-dp44mt-metal-chelator","title":"Dp44mT, Metal chelator","description":"\u003cp\u003eA metal chelator with potent antitumor activity. Displays an average IC50 of 30 nM over 28 cancer cell lines (IC50 range 5 nM to 400 nM). Dp44mT retained its antiproliferative activity in both etoposide-resistant MCF-7\/VP clones (MCF-7 breast cancer cells) and vinblastine-resistant KB-VB1 clones (KB3-1 epidermoid carcinoma cells) with an IC50 = 12 nM for both lines. The potency of Dp44mT has been attributed to the high redox activity of the Dp44mT-Fe complex leading to cytotoxic ROS generation. The antitumor activity of Dp44mT may also be mediated by a redox active copper complex that causes cellular glutathione depletion and lysosomal damage. It also inhibits T-cell activation and prevented CD25 up-regulation via a copper-dependent mechanism\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410885747028,"sku":"ABM146947-1","price":123.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410885779796,"sku":"ABM146947-2","price":41.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4951.png?v=1791103409","url":"https:\/\/www.abmium.com\/de\/products\/tribio-dp44mt-metal-chelator","provider":"ABMIUM","version":"1.0","type":"link"}