{"product_id":"tribio-dbic-dnmt3b-s-nitrosylation-inhibitor","title":"DBIC, DNMT3B S-nitrosylation inhibitor","description":"\u003cp\u003eSpecifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50≤100 nM, without affecting its enzymatic activity. Treatment with DBIC prevents nitric oxide-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced NO production. DNMT3B-mediated DNA methylation is regulated by S-nitrosylaton and DBIC represents a new useful tool for studying this system. A negative control compound, DBIC-neg2 (Cat # MC-5162) is also available\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410884600148,"sku":"ABM146894-1","price":490.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410884632916,"sku":"ABM146894-2","price":123.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI5161.png?v=1791103406","url":"https:\/\/www.abmium.com\/de\/products\/tribio-dbic-dnmt3b-s-nitrosylation-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}