{"product_id":"tribio-cct251236-hsf1-inhibitor","title":"CCT251236, HSF1 inhibitor","description":"\u003cp\u003eAn inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction). It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410885550420,"sku":"ABM146797-1","price":531.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410885583188,"sku":"ABM146797-2","price":147.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4410.png?v=1791103408","url":"https:\/\/www.abmium.com\/de\/products\/tribio-cct251236-hsf1-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}