{"product_id":"tribio-caspase-1-colorimetric-assay-kit","title":"Caspase-1 Colorimetric Assay Kit","description":"\u003cp\u003eApoptosis plays a fundamental role in many normal biological processes as well as in several disease states. Apoptosis can be induced by various stimuli that all produce the same end result: systematic and orderly cell death. The inflammasome is a large multiprotein complex whose assembly leads to the activation of caspase-1, which promotes the maturation of proinflammatory cytokines interleukin-1β (IL-1β) and IL-18\u003c\/p\u003e\n\u003cp\u003eThe TriboTM Caspase-1 Colorimetric Assay Kits provide a simple and convenient means for assaying the activity of caspases that recognize the sequence YVAD. The assay is based on spectrophotometric detection of the chromophore p- nitroaniline (pNA) after cleavage from the labeled substrate YVAD-pNA. The pNA light emission can be quantified using a spectrophotometer or a microtiter plate reader at 400- or 405-nm. Comparison of the absorbance of pNA from an apoptotic sample with an uninduced control allows the determination of the fold increase in caspase-1 activity\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"100tests","offer_id":57410987393364,"sku":"ABM147962-1","price":262.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBS2040-1.jpg?v=1791831412","url":"https:\/\/www.abmium.com\/de\/products\/tribio-caspase-1-colorimetric-assay-kit","provider":"ABMIUM","version":"1.0","type":"link"}