{"product_id":"tribio-bay-876-glut1-inhibitor","title":"BAY-876, GLUT1 inhibitor","description":"\u003cp\u003ePotent inhibitor (IC50 = 2 nM) of the facilitative glucose transporter GLUT1, an enzyme frequently overexpressed in many cancers. It shows greater than 100-fold selectivity over GLUT2-4. BAY-876 displayed potent antitumor activity in ovarian cancer xenograft models and in triple negative breast cancer cells displaying high glycolytic and low oxidative phosphorylation rates. It reduced CD4+ T cell proliferation and IFN-γ secretion via GLUT1 inhibition suggesting utility against auto-inflammatory diseases. BAY-876 induces disulfidptosis in SLCA11high cancer cells\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410865463636,"sku":"ABM146681-1","price":401.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410865496404,"sku":"ABM146681-2","price":131.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4708.png?v=1791103231","url":"https:\/\/www.abmium.com\/de\/products\/tribio-bay-876-glut1-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}