{"product_id":"tribio-anacardic-acid-hat-inhibitor","title":"Anacardic Acid, HAT Inhibitor","description":"\u003cp\u003eAnacardic acids occur in cashew nut shells and are similar in structure to urushiols, the irritating components of poison ivy. Anacardic acid inhibits histone acetyltransferases (HATs) p300 (IC50 = 8.5 µM) and PCAF (IC50 = 5.0 µM) with no effect on HDACs. It also suppresses expression or activity of proteins involved in invasion and angiogenesis, e.g. MMP-2 (IC50 = 11 µM) and -92. 6-PDSA, a saturated form of anacardic acid, induces macrophage activation via MAPK and NF-κB3. When used at 125 µM, it sensitized cancer cells to radiation therapy by reducing histone expression. It also blocks inducible and constitutive activation of NF-κB in leukemia cells\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410859106644,"sku":"ABM146607-1","price":229.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410859139412,"sku":"ABM146607-2","price":57.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4015.png?v=1791103217","url":"https:\/\/www.abmium.com\/de\/products\/tribio-anacardic-acid-hat-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}