{"product_id":"tribio-4-8c-ire1-ribonuclease-inhibitor","title":"4µ8C, IRE1 ribonuclease inhibitor","description":"\u003cp\u003eSelective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity. Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells. Blocks production of IL-4, IL-5 and IL-13 production in T cells. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410864611668,"sku":"ABM146518-1","price":163.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410864644436,"sku":"ABM146518-2","price":53.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1579.png?v=1791103230","url":"https:\/\/www.abmium.com\/de\/products\/tribio-4-8c-ire1-ribonuclease-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}