{"product_id":"reed-biotech-vhl-polyclonal-antibody-ra36059","title":"VHL Polyclonal Antibody","description":"\u003cp\u003evon Hippel-Lindau tumor suppressor(VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G\/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250009088340,"sku":"ABM5040453-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250009121108,"sku":"ABM5040453-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_ffdf0710-ef13-48c6-b800-17161d78a98c.webp?v=1790235501","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-vhl-polyclonal-antibody-ra36059","provider":"ABMIUM","version":"1.0","type":"link"}