{"product_id":"reed-biotech-tab1-n-term-mouse-monoclonal-antibody-ra12054","title":"TAB1 (N-term) Mouse Monoclonal Antibody","description":"\u003cp\u003eTGF-beta activated kinase 1 (MAP3K7) binding protein 1(TAB1) Homo sapiens The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7\/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14\/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57249669644628,"sku":"ABM5042884-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57249669677396,"sku":"ABM5042884-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_0a885342-bd49-4cf2-8c20-e3b0a7764710.webp?v=1790235305","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-tab1-n-term-mouse-monoclonal-antibody-ra12054","provider":"ABMIUM","version":"1.0","type":"link"}