{"product_id":"reed-biotech-smad2-phospho-thr220-polyclonal-antibody-ra21249","title":"Smad2 (phospho Thr220) Polyclonal Antibody","description":"\u003cp\u003eSMAD family member 2(SMAD2) Homo sapiens The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene \u0026amp;apos;mothers against decapentaplegic\u0026amp;apos; (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57248470008148,"sku":"ABM5025643-1","price":137.0,"currency_code":"USD","in_stock":true},{"title":"100 µL","offer_id":57248470040916,"sku":"ABM5025643-2","price":184.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_10f751f8-39f7-488d-8bf6-956e205f3ce5.webp?v=1790235196","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-smad2-phospho-thr220-polyclonal-antibody-ra21249","provider":"ABMIUM","version":"1.0","type":"link"}