{"product_id":"reed-biotech-sirt5-rabbit-polyclonal-antibody-ra36915","title":"SIRT5 Rabbit Polyclonal Antibody","description":"\u003cp\u003eNAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically\u003cbr\u003eremoves malonyl, succinyl and glutaryl groups on target proteins . Activates CPS1 and\u003cbr\u003econtributes to the regulation of blood ammonia levels during prolonged fasting: acts by\u003cbr\u003emediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting . Activates SOD1 by mediating its\u003cbr\u003edesuccinylation, leading to reduced reactive oxygen species . Activates SHMT2 by\u003cbr\u003emediating its desuccinylation . Modulates ketogenesis through the desuccinylation and\u003cbr\u003eactivation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase\u003cbr\u003eactivity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57249917731156,"sku":"ABM5041309-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57249917763924,"sku":"ABM5041309-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_0e1be0b4-204c-480b-9148-61db8f5f5ca4.webp?v=1790235186","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-sirt5-rabbit-polyclonal-antibody-ra36915","provider":"ABMIUM","version":"1.0","type":"link"}