{"product_id":"reed-biotech-sgo1-phospho-ser14-polyclonal-antibody-ra29777","title":"Sgo1 (phospho Ser14) Polyclonal Antibody","description":"\u003cp\u003eshugoshin 1(SGO1) Homo sapiens The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibro\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57249931460948,"sku":"ABM5034171-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57249931493716,"sku":"ABM5034171-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_af87361a-b232-4968-8378-4cfd8d870607.webp?v=1790235169","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-sgo1-phospho-ser14-polyclonal-antibody-ra29777","provider":"ABMIUM","version":"1.0","type":"link"}