{"product_id":"reed-biotech-p21-polyclonal-antibody-ra20671","title":"p21 Polyclonal Antibody","description":"\u003cp\u003ecyclin dependent kinase inhibitor 1A(CDKN1A) Homo sapiens This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lac\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57248417841492,"sku":"ABM5025065-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57248417874260,"sku":"ABM5025065-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_6086fd8e-3268-4a3e-8418-e101f30b37ce.webp?v=1790234781","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-p21-polyclonal-antibody-ra20671","provider":"ABMIUM","version":"1.0","type":"link"}