{"product_id":"reed-biotech-oaz3-polyclonal-antibody-ra33763","title":"OAZ3 Polyclonal Antibody","description":"\u003cp\u003eornithine decarboxylase antizyme 3(OAZ3) Homo sapiens The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that ho\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57251018375508,"sku":"ABM5038157-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57251018408276,"sku":"ABM5038157-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_9152932c-7629-4659-9c20-463d52d7005b.webp?v=1790234687","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-oaz3-polyclonal-antibody-ra33763","provider":"ABMIUM","version":"1.0","type":"link"}