{"product_id":"reed-biotech-npc1-rabbit-polyclonal-antibody-ra27918","title":"NPC1 Rabbit Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal\/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal\/lysosomal compartments.[provided by RefSeq, Aug 2009],\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57251017294164,"sku":"ABM5032312-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57251017326932,"sku":"ABM5032312-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_5aedfa46-9d2c-4a06-a7b1-ad35b0f77549.webp?v=1790234651","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-npc1-rabbit-polyclonal-antibody-ra27918","provider":"ABMIUM","version":"1.0","type":"link"}