{"product_id":"reed-biotech-ndr2-polyclonal-antibody-ra27635","title":"NDR2 Polyclonal Antibody","description":"\u003cp\u003ecatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1\/MOBKL1A and MOB2\/HCCA2 to the N-terminal of STK38L.,function:Involved in the regulation of structural processes in differentiating and mature neuronal cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. AGC Ser\/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Associated with the actin cytoskeleton.,subunit:Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2.,tissue specificity:Ubiquitously expressed with highest levels observed in the thymus.,\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57251030696276,"sku":"ABM5032029-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57251030729044,"sku":"ABM5032029-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_8d2c4ad5-ad99-4278-bc34-15232fbdddbf.webp?v=1790234589","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-ndr2-polyclonal-antibody-ra27635","provider":"ABMIUM","version":"1.0","type":"link"}