{"product_id":"reed-biotech-mib2-polyclonal-antibody-ra33313","title":"MIB2 Polyclonal Antibody","description":"\u003cp\u003efunction:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated. Possibly via autoubiquitination.,similarity:Contains 1 ZZ-type zinc finger.,similarity:Contains 2 MIB\/HERC2 domains.,similarity:Contains 2 RING-type zinc fingers.,similarity:Contains 9 ANK repeats.,subcellular location:Colocalizes with endosomal compartments.,subunit:Interacts with actin monomer.,tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.,\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250215166292,"sku":"ABM5037707-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250215199060,"sku":"ABM5037707-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_009da768-a4fb-4fd5-ac7d-c3bdad1a6c07.webp?v=1790234484","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-mib2-polyclonal-antibody-ra33313","provider":"ABMIUM","version":"1.0","type":"link"}