{"product_id":"reed-biotech-limk-2-phospho-thr505-polyclonal-antibody-ra21137","title":"LIMK-2 (phospho Thr505) Polyclonal Antibody","description":"\u003cp\u003eLIM domain kinase 2(LIMK2) Homo sapiens There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57248210485588,"sku":"ABM5025531-1","price":137.0,"currency_code":"USD","in_stock":true},{"title":"100 µL","offer_id":57248210518356,"sku":"ABM5025531-2","price":184.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody.webp?v=1790791467","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-limk-2-phospho-thr505-polyclonal-antibody-ra21137","provider":"ABMIUM","version":"1.0","type":"link"}