{"product_id":"reed-biotech-dok-3-polyclonal-antibody-ra24295","title":"Dok-3 Polyclonal Antibody","description":"\u003cp\u003edomain:PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D\/SHIP1. May modulate ABL function.,PTM:Constitutively tyrosine-phosphorylated.,PTM:On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.,similarity:Belongs to the DOK family. Type A subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:On tyrosine phosphorylation, interacts with CSK and INPP5D\/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP.,tissue specificity:Expressed in spleen.,\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57249957183828,"sku":"ABM5028689-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57249957216596,"sku":"ABM5028689-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody.webp?v=1790791467","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-dok-3-polyclonal-antibody-ra24295","provider":"ABMIUM","version":"1.0","type":"link"}