{"product_id":"reed-biotech-bestrophin-1-polyclonal-antibody-ra22382","title":"Bestrophin-1 Polyclonal Antibody","description":"\u003cp\u003ebestrophin 1(BEST1) Homo sapiens This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008],\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250395783508,"sku":"ABM5026776-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250395816276,"sku":"ABM5026776-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody.webp?v=1790791467","url":"https:\/\/www.abmium.com\/de\/products\/reed-biotech-bestrophin-1-polyclonal-antibody-ra22382","provider":"ABMIUM","version":"1.0","type":"link"}