{"product_id":"rabbit-polyclonal-antibody-to-wdr40a-p31597","title":"Anti-WDR40A Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eDCAF12\u003c\/strong\u003e is a substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58031505244500,"sku":"ABM414771-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58031505277268,"sku":"ABM414771-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58031505310036,"sku":"ABM414771-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-wdr40a-p31597","provider":"ABMIUM","version":"1.0","type":"link"}