{"product_id":"rabbit-polyclonal-antibody-to-sufu-p42790","title":"Anti-SUFU Rabbit Polyclonal Antibody","description":"\u003cp\u003eNegative regulator in the hedgehog\/smoothened signalling pathway that acts by sequestering the GLI (GI1, GLI2 and GLI3) transcription factors in the cytoplasm. When smoothened signalling is initiated, GLI transcription factors dissociate from SUFU, translocate to the nucleus and activate expression of target genes. In absence of smoothened signalling, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of full-length GLI3 into transcription repressor GLI3R: SUFU participates to GLI3 processing by promoting recruitment of GSK3B to GLI3.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58167053418836,"sku":"ABM419803-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58167053451604,"sku":"ABM419803-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58167053484372,"sku":"ABM419803-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-sufu-p42790","provider":"ABMIUM","version":"1.0","type":"link"}