{"product_id":"rabbit-polyclonal-antibody-to-smurf2-p33924","title":"Anti-SMURF2 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eSMURF2\u003c\/strong\u003e is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. SMURF2 interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta\/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signalling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58157221151060,"sku":"ABM416783-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58157221183828,"sku":"ABM416783-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58157221216596,"sku":"ABM416783-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-smurf2-p33924","provider":"ABMIUM","version":"1.0","type":"link"}