{"product_id":"rabbit-polyclonal-antibody-to-shmt1-n-term-p33986","title":"Anti-SHMT1 (N-term) Rabbit Polyclonal Antibody","description":"\u003cp\u003ePyridoxal phosphate (PLP)-dependent enzyme that catalyses the reversible conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF, serving as a critical component of the folate cycle and facilitating one-carbon biosynthetic reactions essential for methionine, purine, and pyrimidine synthesis. While its central activity involves serine cleavage, the detailed catalytic mechanisms remain under study, including both retro-aldol cleavage of the PLP-serine C(alpha)-C(beta) bond followed by formaldehyde condensation with THF, and alternative nucleophilic displacement mechanisms of the C(alpha) atom of PLP-serine aldimine involving THF's N5 atom.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58157229375828,"sku":"ABM416836-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58157229408596,"sku":"ABM416836-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58157229441364,"sku":"ABM416836-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-shmt1-n-term-p33986","provider":"ABMIUM","version":"1.0","type":"link"}