{"product_id":"rabbit-polyclonal-antibody-to-ripk2-p33581","title":"Anti-RIPK2 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eRIPK2\u003c\/strong\u003e is a serine\/threonine\/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. RIPK2 acts as a key effector of NOD1 and NOD2 signalling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58157114523988,"sku":"ABM416460-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58157114556756,"sku":"ABM416460-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58157114589524,"sku":"ABM416460-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-ripk2-p33581","provider":"ABMIUM","version":"1.0","type":"link"}