{"product_id":"rabbit-polyclonal-antibody-to-raf1-p23300","title":"Anti-Raf1 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eRAF1\u003c\/strong\u003e is a serine\/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK\/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1\/MEK1 and MAP2K2\/MEK2) and the extracellular signal-regulated kinases (MAPK3\/ERK1 and MAPK1\/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD\/Bcl2-antagonist of cell death at 'Ser-75'.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58031132246356,"sku":"ABM413021-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58031132279124,"sku":"ABM413021-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58031132311892,"sku":"ABM413021-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-raf1-p23300","provider":"ABMIUM","version":"1.0","type":"link"}