{"product_id":"rabbit-polyclonal-antibody-to-ptch1-p23171","title":"Anti-PTCH1 Rabbit Polyclonal Antibody","description":"\u003cp\u003eNegative regulator of the smoothened signalling pathway, which acts as a receptor for hedgehog (SHH, IHH and DHH) morphogens. In absence of hedgehog, acts as an inhibitor of smoothened protein (SMO) by preventing SMO access to cholesterol: mechanistically, acts as a cholesterol transporter, which depeletes cholesterol from the outer leaflet of plasma membrane, thereby preventing cholesterol-binding to the extracellular CRD region of SMO. Hedgehog-binding inhibits PTCH1 cholesterol transporter activity, promoting SMO activation by cholesterol and transduction of the smoothened signalling pathway.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58024730624340,"sku":"ABM412905-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58024730657108,"sku":"ABM412905-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58024730689876,"sku":"ABM412905-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/enP231713.jpg?v=1793205256","url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-ptch1-p23171","provider":"ABMIUM","version":"1.0","type":"link"}