{"product_id":"rabbit-polyclonal-antibody-to-p90rsk-ab-348-p41351","title":"Anti-p90RSK(Ab-348) Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eRPS6KA1\u003c\/strong\u003e is a serine\/threonine-protein kinase that acts downstream of ERK (MAPK1\/ERK2 and MAPK3\/ERK1) signalling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1\/ER81 and NR4A1\/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signalling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1\/NUR77 and ETV1\/ER81 transcription factors and the cofactor CREBBP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58162365989204,"sku":"ABM418596-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58162366021972,"sku":"ABM418596-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58162366054740,"sku":"ABM418596-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-p90rsk-ab-348-p41351","provider":"ABMIUM","version":"1.0","type":"link"}