{"product_id":"rabbit-polyclonal-antibody-to-irf5-phospho-ser437-p43935","title":"Anti-IRF5 (Phospho-Ser437) Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eIRF5\u003c\/strong\u003e is a transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. IRF5 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. IRF5 can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58167832314196,"sku":"ABM420685-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58167832346964,"sku":"ABM420685-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58167832379732,"sku":"ABM420685-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-irf5-phospho-ser437-p43935","provider":"ABMIUM","version":"1.0","type":"link"}