{"product_id":"rabbit-polyclonal-antibody-to-fnip2-p06532","title":"Anti-FNIP2 Rabbit Polyclonal Antibody","description":"\u003cp\u003eBinding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signalling cascade controlling the MiT\/TFE factors TFEB and TFE3. FNIP2 is required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signalling. In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58006616736084,"sku":"ABM402724-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58006616768852,"sku":"ABM402724-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58006616801620,"sku":"ABM402724-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-fnip2-p06532","provider":"ABMIUM","version":"1.0","type":"link"}