{"product_id":"rabbit-polyclonal-antibody-to-dc12-c-term-p30888","title":"Anti-DC12  (C-term) Rabbit Polyclonal Antibody","description":"\u003cp\u003eSensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. HMCES acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. HMCES promotes error-free repair by protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58031387935060,"sku":"ABM414112-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58031387967828,"sku":"ABM414112-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58031388000596,"sku":"ABM414112-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-dc12-c-term-p30888","provider":"ABMIUM","version":"1.0","type":"link"}