{"product_id":"rabbit-polyclonal-antibody-to-cklf6-p42360","title":"Anti-CKLF6 Rabbit Polyclonal Antibody","description":"\u003cp\u003eMaster regulator of recycling and plasma membrane expression of PD-L1\/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1\/CD274 at recycling endosomes, where it protects PD-L1\/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. CMTM6 may stabilize PD-L1\/CD274 expression on antigen presenting cells and potentiates inhibitory signalling by PDCD1\/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58166869164372,"sku":"ABM419417-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58166869197140,"sku":"ABM419417-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58166869229908,"sku":"ABM419417-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-cklf6-p42360","provider":"ABMIUM","version":"1.0","type":"link"}