{"product_id":"rabbit-polyclonal-antibody-to-birc2-p07637","title":"Anti-BIRC2 Rabbit Polyclonal Antibody","description":"\u003cp\u003eMulti-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signalling and immunity, mitogenic kinase signalling, and cell proliferation, as well as cell invasion and metastasis. BIRC2 acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signalling and regulates both canonical and non-canonical NF-kappa-B signalling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signalling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO\/SMAC, MAP3K14\/NIK, MAP3K5\/ASK1, IKBKG\/NEMO, IKBKE and MXD1\/MAD1.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58006738534740,"sku":"ABM403382-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58006738567508,"sku":"ABM403382-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58006738600276,"sku":"ABM403382-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-birc2-p07637","provider":"ABMIUM","version":"1.0","type":"link"}