{"product_id":"rabbit-polyclonal-antibody-to-aplnr-p42758","title":"Anti-APLNR Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eAPLNR\u003c\/strong\u003e is a G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA\/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis. When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor. APLNR\/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G protein-independent fashion to induce beta-arrestin signalling, hence eliciting cardiac hypertrophy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58167043785044,"sku":"ABM419779-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58167043817812,"sku":"ABM419779-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58167043850580,"sku":"ABM419779-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/de\/products\/rabbit-polyclonal-antibody-to-aplnr-p42758","provider":"ABMIUM","version":"1.0","type":"link"}