{"product_id":"proteogenix-recombinant-mouse-crisp2-protein-n-his","title":"Recombinant Mouse CRISP2 Protein, N-His","description":"\u003ch2\u003eIntroduction\u003c\/h2\u003e \u003cp\u003eRecombinant Mouse CRISP2 Protein is a type of recombinant protein that has been extensively studied in recent years due to its diverse functions and potential applications in various fields. This protein belongs to the CRISP (Cysteine-Rich Secretory Proteins) family and is highly expressed in the male reproductive system, specifically in the testes and epididymis. In this article, we will provide a scientific description of the structure, activity, and applications of Recombinant Mouse CRISP2 Protein.\u003c\/p\u003e \u003ch2\u003eStructure\u003c\/h2\u003e \u003cp\u003eRecombinant Mouse CRISP2 Protein is a 25 kDa protein that consists of 222 amino acids. It has a conserved cysteine-rich domain, which is characteristic of the CRISP family. This domain is responsible for the protein’s structure and function, and it contains 16 cysteine residues that form disulfide bonds to stabilize the protein’s tertiary structure.\u003c\/p\u003e \u003cp\u003eThe crystal structure of Recombinant Mouse CRISP2 Protein has been determined, revealing a compact globular protein with a central core and two protruding loops. This structure is similar to other CRISP family members, indicating a conserved function among these proteins.\u003c\/p\u003e \u003ch2\u003eActivity\u003c\/h2\u003e \u003cp\u003eRecombinant Mouse CRISP2 Protein has been shown to have several activities, including ion channel blocking, protease inhibition, and sperm binding. These activities are crucial for the protein’s role in male reproductive function.\u003c\/p\u003e \u003cp\u003eOne of the most well-studied activities of Recombinant Mouse CRISP2 Protein is its ability to block ion channels. It has been shown to inhibit both voltage-gated and ligand-gated ion channels, which are essential for sperm motility and fertilization. This activity is thought to be due to the protein’s ability to interact with the lipid membrane of the sperm cell, disrupting ion channel function.\u003c\/p\u003e \u003cp\u003eIn addition to ion channel blocking, Recombinant Mouse CRISP2 Protein also exhibits protease inhibition activity. It has been shown to inhibit several proteases, including trypsin and chymotrypsin, which are involved in sperm maturation and function. By inhibiting these proteases, Recombinant Mouse CRISP2 Protein may play a role in regulating sperm development and function.\u003c\/p\u003e \u003cp\u003eAnother important activity of Recombinant Mouse CRISP2 Protein is its ability to bind to sperm cells. This binding is thought to be mediated by the protein’s interaction with glycosaminoglycans on the surface of the sperm cell. This activity may be crucial for sperm-egg interaction and fertilization.\u003c\/p\u003e \u003ch2\u003eApplication\u003c\/h2\u003e \u003cp\u003eRecombinant Mouse CRISP2 Protein has potential applications in various fields due to its diverse activities and functions. One of the most promising applications is in male contraception. By targeting sperm function and development, Recombinant Mouse CRISP2 Protein may serve as a potential target for male contraceptive drugs.\u003c\/p\u003e \u003cp\u003eIn addition to contraception, Recombinant Mouse CRISP2 Protein may also have applications in fertility treatments. It has been shown to play a role in sperm-egg interaction and fertilization, making it a potential target for improving fertility in both males and females.\u003c\/p\u003e \u003cp\u003eFurthermore, Recombinant Mouse CRISP2 Protein has been studied for its potential role in the treatment of certain cancers. It has been shown to inhibit the growth and metastasis of prostate cancer cells, making it a potential therapeutic target for this type of cancer.\u003c\/p\u003e \u003ch2\u003eConclusion\u003c\/h2\u003e \u003cp\u003eIn summary, Recombinant Mouse CRISP2 Protein is a 25 kDa protein with a conserved cysteine-rich domain. It exhibits various activities, including ion channel blocking, protease inhibition, and sperm binding. These activities make it a potential target for male contraception, fertility treatments, and cancer therapy. Continued research on this protein may lead to the development of novel treatments and therapies in the future.\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number ARO-P10952. For research use only.\u003c\/p\u003e\u003cp\u003eHost: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 27.35 kDa; Fragment: Lys23-His243; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/ARO-P10952.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57358842298708,"sku":"ABM141391-1","price":135.2,"currency_code":"GBP","in_stock":true},{"title":"100ug","offer_id":57358842331476,"sku":"ABM141391-2","price":220.0,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":57358842364244,"sku":"ABM141391-3","price":679.2,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/3d-representation-image-recombinant-mouse-crisp2-protein-n-his_d842a5be-a39f-45bd-b2ca-ad8978debe69.webp?v=1791501016","url":"https:\/\/www.abmium.com\/de\/products\/proteogenix-recombinant-mouse-crisp2-protein-n-his","provider":"ABMIUM","version":"1.0","type":"link"}