{"product_id":"proteogenix-recombinant-mouse-cd267-tnfrsf13b-protein-n-his","title":"Recombinant Mouse CD267\/TNFRSF13B Protein, N-His","description":"\u003cp\u003eRecombinant Mouse CD267\/TNFRSF13B Protein, also known as B-cell maturation antigen (BCMA), is a type III transmembrane protein that belongs to the tumor necrosis factor receptor superfamily. It is primarily expressed on the surface of B cells and plays a crucial role in regulating B cell survival and differentiation. Recombinant Mouse CD267\/TNFRSF13B Protein is a valuable tool for research in immunology and cancer biology, and has potential therapeutic applications in various diseases.\u003c\/p\u003e \u003ch2\u003eStructure of Recombinant Mouse CD267\/TNFRSF13B Protein\u003c\/h2\u003e \u003cp\u003eRecombinant Mouse CD267\/TNFRSF13B Protein is a 184 amino acid protein with a predicted molecular weight of approximately 21 kDa. It consists of a signal peptide, a cysteine-rich domain, four extracellular cysteine-rich repeats, a transmembrane domain, and a cytoplasmic tail. The extracellular domain of Recombinant Mouse CD267\/TNFRSF13B Protein contains the binding site for its ligand, B-cell activating factor (BAFF), and its homolog, a proliferation-inducing ligand (APRIL).\u003c\/p\u003e \u003cp\u003eThe crystal structure of Recombinant Mouse CD267\/TNFRSF13B Protein has been determined, revealing a trimeric assembly of the extracellular domain. The trimeric structure is essential for ligand binding and signal transduction. The cytoplasmic tail of Recombinant Mouse CD267\/TNFRSF13B Protein contains a conserved death domain, which is crucial for activating downstream signaling pathways.\u003c\/p\u003e \u003ch2\u003eActivity of Recombinant Mouse CD267\/TNFRSF13B Protein\u003c\/h2\u003e \u003cp\u003eRecombinant Mouse CD267\/TNFRSF13B Protein is a key regulator of B cell function and survival. Its main function is to bind to BAFF and APRIL, which are essential factors for B cell development and maturation. By binding to these ligands, Recombinant Mouse CD267\/TNFRSF13B Protein activates signaling pathways that promote B cell survival and proliferation. It also plays a role in regulating the production of antibodies by B cells.\u003c\/p\u003e \u003cp\u003eIn addition to its role in B cell biology, Recombinant Mouse CD267\/TNFRSF13B Protein has been implicated in the pathogenesis of various diseases. It has been shown to be overexpressed in multiple myeloma, a type of blood cancer, and may contribute to the survival and growth of cancer cells. Recombinant Mouse CD267\/TNFRSF13B Protein has also been linked to autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, as well as inflammatory conditions like multiple sclerosis and inflammatory bowel disease.\u003c\/p\u003e \u003ch2\u003eApplication of Recombinant Mouse CD267\/TNFRSF13B Protein\u003c\/h2\u003e \u003cp\u003eRecombinant Mouse CD267\/TNFRSF13B Protein has a wide range of applications in both research and therapeutic settings. In research, it is commonly used as a tool to study B cell biology, including B cell survival, proliferation, and antibody production. It is also used to investigate the role of Recombinant Mouse CD267\/TNFRSF13B Protein in diseases such as cancer and autoimmune disorders.\u003c\/p\u003e \u003cp\u003eIn the field of therapeutics, Recombinant Mouse CD267\/TNFRSF13B Protein has shown promise as a potential target for the treatment of various diseases. Several monoclonal antibodies targeting Recombinant Mouse CD267\/TNFRSF13B Protein have been developed and are currently being evaluated in clinical trials for the treatment of multiple myeloma and other B cell malignancies. In addition, Recombinant Mouse CD267\/TNFRSF13B Protein has been identified as a potential target for the treatment of autoimmune diseases, and drugs targeting this protein are currently in development.\u003c\/p\u003e \u003cp\u003eIn conclusion, Recombinant Mouse CD267\/TNFRSF13B Protein\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number ARO-P10464. For research use only.\u003c\/p\u003e\u003cp\u003eHost: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 11.30 kDa; Fragment: Met1-Arg79; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/ARO-P10464.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57358789378388,"sku":"ABM140905-1","price":196.0,"currency_code":"GBP","in_stock":true},{"title":"100ug","offer_id":57358789411156,"sku":"ABM140905-2","price":279.2,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":57358789443924,"sku":"ABM140905-3","price":751.2,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/3d-representation-image-recombinant-mouse-cd267-tnfrsf13b-protein-n-his_6a5bc8cf-6b2b-445c-8ce2-97ff485869e0.webp?v=1790893762","url":"https:\/\/www.abmium.com\/de\/products\/proteogenix-recombinant-mouse-cd267-tnfrsf13b-protein-n-his","provider":"ABMIUM","version":"1.0","type":"link"}